Antioch on the Orontes—also sometimes called “Syrian Antioch”— was the third-largest city in the Greco–Roman world: behind Rome and Alexandria (Egypt). Today it is called Antakya (Hatay) and has a population of about 150,000.
Here followers of Jesus were first called “Christians” (Acts 11:19–26) and from here famine relief was sent to Jerusalem (Acts 11:27–30). Paul began all three of his missionary journeys from Antioch (Acts 13; 15:35–41; 18:22–23).
There were at least sixteen Antiochs in the Greco–Roman world. The other Antioch mentioned in the New Testament is “Pisidian Antioch.”